Enhancement of Mutagenic Actiyity of 9 - into the Molecule Aminoacridineby Introducing a Nitro Group
نویسنده
چکیده
Mutagenic activity and DNA interca]ation were examined for 9-aminoacridine (9-AA) and its deriyatiyes. Introduction of a nitro group into the 9-AA molecule was found to enhance the actiyity enormously as was detected by the Ames test. Acetylation of amino group at 9-position of acridine ring inhibited the intercalation, the frameshift activity disappearing. Rat liyer S9 conyerted 9-AA metabolically to 9-amino2-hydroxyacridine.
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